Day :
- Session: Pharmacology and Toxicology | Cancer | Clinical Therapies | Cancer Causes | Oncology Nursing | Drug Discovery and Drug Screening | Cancer Genetics and Epigenetics
Session Introduction
B Singh and P R Gajurel
North Eastern Regional Institute of Science and Technology, India
Title: Pharmacological potential medicinal plants of Indian Eastern Himalaya: Note on present status of occurrence and conservation
Time : 11:05-11:40
Biography:
Abstract:
Nasira Tajamal
OGDCL Medical Center, Pakistan
Title: Incidence of Colorectal Carcinoma in Young Population of Islamabad
Time : 11:40-12:15
Biography:
Abstract:
P R Gajurel and B Singh
North Eastern Regional Institute of Sciences and Technology, India
Title: Ethnomedicinal plants and their uses by the indigenous people of north east India: Prospects of ethno-pharmacological application
Time : 12:15-12:50
Biography:
Abstract:
Elham Bidram
University of Melbourne, Australia
Title: Targeted graphene oxide networks as a novel cancer treatment
Biography:
Elham Bidram has finished her PhD at chemical & Biomolecular Engeering from University of Melbourne. Her project was focused on new polymeric system designed for cancer therapy using 2D carbon polymers. She just started her post-doctoral studies at Faculty of Advanced Sciences & Technologies in University of Isfahan. Isfahan.
Abstract:
An effective strategy to inhibit endocytosis in tumorcells is presented. The results suggest that the binding connects neighboring receptors, neutralises endocytosis,and causesmetabolic deprivation.As a result, tumour cell survival and proliferation are reduced.Live cell confocal microscopy imaging reveals that the cellular interaction of these modified networks dependedon the surface chemistry. In vitro exposure of tumor cells to this system reduces the cell viability by 35% compared to a 50% reduction using methotrexate (100 μM). The combination of the modified networks with methotrexate (MTX) or doxorubicin (DOX) showsa greater toxicity(80% reduction in cell viability) than the individual agents. The proposed setup demonstrates a significant synergy in limiting tumour cellgrowth.
Khalid Aftab
Sialkot Medical College, Pakistan
Title: Bioassay-directed isolation of hypotensive alkaloids from Holarrhena pubescens
Biography:
Abstract:
Nasira Tajamal
OGDCL Medical Center, Pakistan
Title: Incidence and prognosis of breast cancer among the females of Islamabad
Biography:
Abstract:
Biography:
Abstract:
Dr. Kazuko Tatsumura
Director Gaia Holistic Health USA and Japan
Title: Effects of Far-Infrared & Terahertz Onnetsu Therapy on Rheumatoid Arthritis and Various Cancers
Biography:
Graduated from Toho Academy of Music in Tokyo, as a pianist and composer, invited by the Boston Symphony,she came to the USA in 1961 as one of the first Japanese women. She then received Master of Art from New York University and finished her Ph.D. credits in Philosophy in 1965. In 1967, Tatsumura then turned to an independent career and became the top International Classical and Cultural Impresario/producer. Until 1992, she produced an average of 2,000 cultural events each year, traveling to more than 140 countries. She was presented with numerous honors for her work. She studied Oriental Traditional Medicine of Japan, Korea, Taiwan and China. In 2,000 she received her PHD and OMD from the International Academy of Education in Tokyo. She established the Oki-Do Holistic Health Center in 1994 in NY and in 2001 the GAIA Holistic Center (501C3 nonprofit organization)at the wake of 9/11 tragedy, for body mind and spirit, aiming for the noninvasive natural healing methods based on the wisdom of the East. Dr. Kazuko Tatsumura has written numerous articles and several books: FE “Overcoming Cancer and Other Diseases in a Holistic Way”, “Your Immune Revolution & Healing Your Healing Power “(with Toru Abo, M.D.) Dr. Kazuko has been invited as a speaker at World Congresses of Holistic Health. She teaches and lectures all over the world. She has received many honors from different countries, many for humanitarian causes. She is well known as a philanthropist.
Abstract:
Onnetsu means comfortable heat. Dr Kazuko Onnetsu Therapy invented by Dr. Kazuko Tatsumura Hillyer emits froma special ceramic;
1) Precise 8-10μ of vibration of Infrared SunRay.
2) Vibration of Terahertz, and
3)various degrees of heat.
When Onnetsuki is slid over the skin, healthy areas are comfortable, but IF deep tissue is cold, unhealthy or degenerated, “hot spot” is detected by the temperature sensation reported from the patient. Dr Kazuko Onnetsu Therapy is both a diagnostic and therapeutic. When this hot spot is effectively treated with Far-Infrared, Terahertz & Heat, Dr Kazuko Onnetsu Therapy, the hot sensation subsides and the Disease conditions improve. Dr. Kazuko’s protocol must be followed. Dr Kazuko Onnetsu Therapy is based on four historical and scientific facts.
1. NASA's finding regarding Far-Infrared vibration from Sun light 8-10μ only. Also, added is the specific Terahertz vibration: .Healing vibration
2. Traditional Japanese Concept of the significance of Body Temperature; Raising Cold Temperature.
3. Immunology Theory by Dr. Toru Abo, balancing autonomic nervous system to improve condition of white cells; Raising Immunity.
4. Promoting four flows of Energy through acupuncture technique: blood, body fluid, Oxygen, Ki(Chi)
Dr. Kazuko has taught her Onnetsu Therapy to MDs and health practitioners over the past decades all over the world: are practicing it in the hospitals and clinics. Clinical Trials have shown improvements on cases (including but not limited to) as arthritis, asthma, various cancers, diabetes, tuberculosis and various painful conditions. Clinical studiesfrom Cuba and Peru will be presented.
Yeni Purnamasari
Master Program in Biomedical Science, Faculty of Medicine Brawijaya University, Malang, East Java, Indonesia
Title: Coelomic Fluid Lumbricus rubellus as combination of 5-Fluoucil Has Role In Decreasing FAK and Calcium Intracellular Expression On Colorectal Cancer HT-29 Cell Line
Biography:
Yeni Purnamasari has completed her Master Degree of Biomedical Sicience at the age of 25 from Brawijaya University and now assigned as Internship Doctor in Aisyiyah Hospital Malang in East Java, Indonesia.
Abstract:
Coelomic fluid of the earthworm had a lot of bioactive substances as therapeutic drug and anticancer effect that has been proven in many medical research. The benefit of coelomic fluid as anticancer effect needs further investigation. This study aimed to investigate whether the coelomic fluid of the earthworm Lumbricus rubellus as combination of 5-Fluouracil has role in decreasing focal adhesion kinase (FAK) and calcium intracellular expression (iCa2-) on colorectal cancer HT-29 cell line. HT-29 cells were cultured by adding coelomic fluid with 5-Fluouracil (5,10, and 20 g/ml) and without 5-Fluouracil (0, 20 g/ml) for 24 hours. We assessed the percentage of FAK level using flowcytometri and iCa2+ using immune-fluorescence. The result showed that after treating HT-29 cells with combination of coelomic fluid and 5-Fluouracil in different concentration, the percentage FAK level significantly decreased in dose combination (p < 0.05) and iCa2+ percentage compare each groups was significantly differences (p< 0.05). Corelation between percentage FAK and iCa2+ showed that there is a strong correlation (R = 0.77). This suggest that treating combination coelomic fluid and 5-fluouracil in HT-29 cells made the decrease in FAK percentage and also followed by iCa2+ percentage. Our finding suggested that coelomic fluid of the earthworm Lumbricus rubellus could prove useful as a combination of 5-fluouracil in colorectal cancer therapy.
- Session: Ethno pharmacology | Surgery | Cardiovascular Pharmacology | Cancer Stages | Toxicology | Robotic Surgery | Pharmacogenetics & Pharmacogenomics
Session Introduction
Dr Nasira Tajamal
MBBS, MPH, (Pak) MPH in Medical Epidemiology (USA), Islamabad Pakistan
Title: Incidence of Colorectal Carcinoma in Young Population of Islamabad
Biography:
Abstract:
The purpose of this study is to promote awareness concerning increased incidence of colorectal cancer in younger population and its clinical plus pathological features compared to older patients. This cross-sectional study was conducted from January 2017 to October 2017 on patients with diagnosis of colorectal carcinoma admitted through emergency or outpatient departments to surgical wards of PIMS Hospital, Islamabad. Data concerning age, gender, presentation, site of tumor, surgery performed and TNM staging was used for analysis.
Total numbers of patients studied were 27. Males were17 (63%) and females were 10 (37%). Patients between the ages of 10 to 20 were 4, (15%), out of these patients 2 were declared unfit for surgery because of wide spread tumor within the abdomen as well distant metastasis. There were 9 (33%) patients between the ages of 21 to 30 and among these 4 was inoperable because of widespread disease. Patients between the ages of 31 to 40 were 5 (19%), 2 were inoperable, while cases between the ages of 41 to 50 were 4 (15%). There were 3 (11%) patients between the ages of 51 and 60 and 2 (7%) cases were between the ages of 61 to 70 years. Total 8 (30%) patients were inoperable and they were young patients, therefore colorectal carcinoma is more aggressive in young patients and 18 (82%) patients between the ages of 10 to 50 years had left sided disease.
Biography:
Will be updated soon.
Abstract:
Data of 92 patients diagnosed with borderline ovarian tumours (BOTs) during the period from 2010 to 2017 in the National Cancer Institute (NCI), Cairo University, Egypt were retrospectively evaluated, Median follow up period was 42 months. The mean age at diagnosis was 42.7 yrs. Histopathology was serous in 63%, mucinous in 28.3%, and endometrioid in 3.3%. 65 patients (70.7%) had Stage IA disease, 17 patients had Stage IB disease (18.5%), 4 patients had Stage IC disease (4.3%), 2 patients had Stage II disease (2.2%) and 4 patients had Stage III disease (4.3%) at diagnosis .49 patients (53.3%) underwent fertility sparing surgery, of which 19 patients underwent Unilateral ovarian cystectomy, 5 patients underwent Bilateral ovarian cystectomy, 25 underwent Unilateral salpingo-oopherectomy.43 patients (46.7%) underwent radical surgery including hysterectomy, bilateral salpingo-oopherectomy.39 patients had micropapillary disease (42 %) and 2 patients had microinvasive disease (2.2%) on histopathology.6 patients (6.5 %) had peritoneal implants of which 1 was invasive and 5 were non-invasive. Recurrence rate in the entire study group was 18.5% , 17.6% among patients underwent radical surgery and 82.4% among patients underwent fertility sparing surgery. 12 of the recurrences (70.6%) were borderline whereas 5 were invasive (29.4%). Stages IA and IB had significantly higher disease free survival than other stages. Patients with micro invasion had significantly lower free disease free survival 10.5 (9.52 – 11.5) Vs77.6 (70.9 – 84.1) .Radical surgery had significantly higher FDS than fertility sparing surgery 75.8 (70.2 – 81.4) Vs 68.5(58.2 – 78.8)
Aarti Sharma
Govindrakshak Ayurvedic and Acupuncture centre ,Punjab
Title: Ayurveda a ray of hope for hepatocellular carcinoma
Biography:
Dr Aarti Sharma born 1983 did Bachelor of Ayurvedic medicine and surgery (BAMS) from one of the premier Ayurvedic college , Govt . Ayurvedic college , Patiala (India) in 2007 . Since then she has been practising ayurveda for the treatment of lifestyle disorders, stress, gynaeocolgical issues,hepatic disorders ,arthritis and other chronic ailments in her own clinic named Govindrakshak Ayurvedic and Acupuncture centre , Ludhiana (Punjab). During these years, she also completed Masters in nutrition and dietetics, Post graduate diploma in Acupuncture and moxibustion , Post graduate diploma in yoga and naturopathy along with a short term course in panchkarma . Suggesting a patient about diet, yoga, naturopathy, panchkarma along with Ayurvedic medicines and healthy lifestyle has always helped her patients for better recovery in a short span. She has been presenting her findings at various national and International conferences.Her work has been appreciated in all conferences.
Abstract:
Hepatocellular carcinoma (HCC) is a very fatal disease having its primary origin in liver. Chronic liver disease, Viral hepatitis, alcohol abuse ,aflatoxins, hemochromatosis, alcohol abuse, cirrhosis, exposure to various carcinogens and non alcoholic fatty liver disease are some of the major risk factors associated with primary liver cell malignancy. The case presented here is of male patient who had a very high value of AFP ( Alfa fetoprotein ) tumor marker. His Computed tomography scan and ultrasonography reports clearly diagnosed him for hepatocellular carcinoma (liver cancer). He was given ayurvedic treatment for his hepatocellular carcinoma .He was prescribed herbal decoction of Giloya (Tinospora cordifolia), haldi (Curcuma longa) along with triphala {combination of 3 herbs: amla (Phyllanthus emblica), harada (Terminalia chebula), baheda (Terminalia bellirica)} along with various ayurvedic formulations particularly punarnavarishta and kalmeghasav . Patient showed significant improvement with treatment . His chief complaints of nausea , right abdominal pain, loss of appetite subsided in forty days of treatment . During course of treatment, patient was advised for AFP (Alfa fetoprotein) tumor marker test thrice and in all the three tests performed at different intervals, his reports were found to be in normal range . After around ten months of treatment, patient was advised for ultrasonography which showed miraculous improvement with no abnormality detected. This case study shows Ayurveda, science of life which is most ancient healing science offers a ray of hope for patients suffering from dreadful condition of liver cancer
Abdolsaleh Jafari
University of Tasmania, Australia.
Title: Cost-effectiveness analysis of IEV drug Regimen versus ESHAP Drug regimen for the patients with Hodgkin and Non-Hodgkin’s Lymphoma in Iran
Biography:
Abdolsaleh Jafari is PhD candidate in health economics at Iran University of Medical Sciences, Tehran, Iran and joined the Menzies Institute for Medical Research, University of Tasmania, Australia in July 2018 as adjunct researcher. Before starting PhD programme in Iran, Abdolsaleh worked as instructor and faculty member of department of health economics at Shiraz University of Medical Sciences in Iran for 3 years. Abdosaleh published more than 25 articles in peer review journals.
Abstract:
Chemotherapy for lymph node cancer is often composed of several drugs that are used in a treatment program. The aim of this study was to perform a cost-effectiveness analysis of IEV drug regimen (ifosfamide, epirubicin, and etoposide) versus ESHAP drug regimen (etoposide, methylprednisolone, high-dose cytarabine, and cisplatin) in patients with lymphoma in the south of Iran.
Maybin Kalubula
University of Chinese Academy of Sciences,China
Title: Cervical cancer risk from the use of ‘insunko’ vaginal herb: A sexual discrimination
Biography:
Will be updated soon.
Abstract:
Background
Cervical cancer is the most common cancer in Zambian women, and its upward trend in Zambia in the past decade is worrisome. Multiple sexual partners, early indulgence in sexual activities and the use of vaginal herbs among others have heightened the risk of contracting the Human Papilloma Virus infection, which is the major cause of cervical cancer.
Methods
A qualitative research design on the use of ‘insunko’ vaginal herb coupled with descriptive phenomenological approach was applied, which involved the retrospective and prospective cervical cancer data obtained from patients’ files at the Zambia Cancer Diseases Hospital (CDH). 10 focus group discussions from 10 hospitals across Zambia involving 30 (n =30) Gynecologists and Cervical Cancer Screening Nurses were conducted to determine the extent of use of ‘insunko’ vaginal herb. The samples were 5,719 (n = 5,719) for the descriptive study. Our study was authorised by the National Health Research Authority of Zambia.
Results
Cervical cancer in Zambia mostly affected age groups 30 – 39, 40 – 49 and 50 – 59 years. ‘Insunko’ herb is widely used in Zambia for sniffing (smoking) while women also use it vaginally for sexual pleasure of the male partner during sexual intercourse. Standardised Incidence Rates (SIR) for all ages have been very high in Monze (493.82; 95% CI = 431.07 – 556.57), Lusaka (413.11; 95% CI = 391.2 – 435.02), Katete (319.58; 95% CI = 276.91 – 362.25) and Chipata (305.04; 95% CI = 274.92 – 335.16). Multiple sexual partners and polygamist marriages are associated with cervical cancer incidence with correlation coefficient r = 0.710 and p – value of 0.021. Age groups affected with cervical cancer are associated with women known to be using ‘insunko’ vaginal herb with p – value = 0.019.
Conclusions
The upward trend of cervical cancer in Zambia has been triggered by the culture of having multiple sexual partners and early indulgence in sexual activities. The use of ‘insunko’ vaginal herb is a kind of sexual discrimination with serious health consequences in women. The government should initiate and implement policies to fight the ignorant sexual culture in order to protect women’s rights
Chen YCE
University of Queensland Diamantina Institute, Australia
Title: Activation of FcγR-dependent responses to therapeutic antibodies by Nurse Like cells requires PI3Kδ
Biography:
Yu-Chen Enya Chen is studying her PhD degree at University of Queensland. Is on third year of PhD and has published a review paper as first author in BBA Cancer Review 2017 (Chen et al.). Is in progress in publishing her second paper. Her PhD project so far has presented an interesting study towards the understanding of the antibody resistant of patients with progressive chronic lymphocytic leukaemia disease. The study shows the evidence of the importance of macrophages as a major contributor to CLL diseases progression.
Abstract:
Antibody therapies for treating chronic lymphocytic leukaemia (CLL) remain a challenge for many CLL patients who are insensitive to antibody treatment. A high percentage of CLL patients that are resistant to the current combination therapy of chemotherapeutics and immune-therapeutics has always been a clinical challenge. Understanding the mechanisms driving disease progression and treatment resistance is key to improving patient outcomes. Many studies including our own laboratories have shown that resistance to therapeutic antibodies against CLL is due to the survival signals from the monocyte derived macrophages (MDMs), and also an acquired resistance of monocyte derived macrophages to participate in FcγR-dependent antitumour responses. However, the FcγR-dependent signalling pathway in macrophages has not been well studied. Our recently published data suggested that SYK and BTK are involved downstream of FcγR-dependent signalling pathway (referred to as ITAM; Oncogene, 36(17):2366-2376, 2017). In this study we investigate the involvement of PI3K isoforms as they have been known to be an important pathway regulator for cellular function in various immune cells such as T cells, B cells and NK cells as well as in cancerous cells. To examine the expression and involvement PI3K isoforms in contributing to FcγR-dependent ADCC by MDMs, we used different inhibitors to specifically target each PI3K isoform at a time to investigate the effect on ADCC responses by MDMs. Examination of PI3K expression showed that PI3Kα, β, and δ are expressed in MDM whereas PI3Kγ is below the limit of detection. We also reported that the PI3Kδ-selective inhibitor, idelalisib and the pan PI3K inhibitor BKM120 (Buparlisib) were able to inhibit ADCC in response to the CD20-targeting therapeutic antibody, obinutuzumab. Similarly, both buparlisib and idelalisib were able to inhibit AKT phosphorylation at concentrations that also inhibited ADCC.
This is the first report to show that PI3Kd is involved in FcgR signalling in MDMs from CLL patients or in MDMs from any tumour type. Based on these findings we conclude that PI3Kd is a critical effector molecule for antitumour responses to therapeutic antibodies in CLL.
Maybin Kalubula
University of Chinese Academy of Sciences, China
Title: Determination of toxic heavy metals and carcinogens in ‘insunko’ Zambian herb: An important Public Health issue.
Biography:
Will be updated soon.
Abstract:
Background
There has emerged an herb in Zambia called ‘insunko’ which is widely used for snuffing while females also use it vaginally to make their private part tight and warm during sexual intercourse. The consumption of ‘insunko’ Zambian herb, which has an unknown chemical composition, has brought mixed feelings among many Zambians. This study therefore aimed at determining toxicity and carcinogenicity of ‘insunko’ Zambian herb.
Methods
Samples were collected from six of the ten provinces of Zambia namely; Eastern, Lusaka, Luapula, Muchinga, Copperbelt and North Western between 4th December 2017 and 4th February 2018 after ethical clearance from the National Health Research Authority of Zambia ‘Insunko’ Zambian herb was sampled by way of purchasing from Chipata, Lusaka, Mpika, Mwense, Kitwe and Solwezi (n = 6). ICP-MS Inductively Coupled Plasma Mass Spectroscopy (Agilent Technologies, Santa Clara, CA, USA) was used for toxic heavy metals analysis. ð¶ð‘Žð‘Ÿð‘ð‘–ð‘›ð‘œð‘”ð‘’ð‘›ð‘–ð‘ risk = CDIing× ðµð´ð¹ × ð‘†ð¿ð¹; ð»ð‘Žð‘§ð‘Žð‘Ÿð‘‘ ð¼ð‘›ð‘‘ð‘’ð‘¥ (ð»ð¼) = C DIing × ðµð´ð¹. ð‘…ð‘“D0
Results
Toxic heavy metals have been detected in ‘insunko’ Zambian herb in high concentration. The Mean concentration ± SD in mg kg-1 was; Arsenic = 0.07 ± 0.04, Cadmium = 0.13 ± 0.05, Cobalt = 0.49 ± 0.27, Chromium = 1.46 ± 1.04, Copper = 5.58 ± 2.91, Manganese = 77.05 ± 35.29, Nickel = 0.91 ± 0.52 and Lead = 0.79 ± 1.22. Hazard Index for Chromium, Manganese, Copper and Arsenic was greater than one (HI > 1) implying that these heavy metals are toxic and carcinogenic to consumers of ‘insunko’ Zambian herb.
Conclusions
‘Insunko’ Zambian herb is toxic and carcinogenic as in contains toxic and carcinogenic heavy metals in high concentration. These toxic metals cause cancers, GIT disorders, degenerative, hematopoietic, cardiovascular, neurologic and cognitive problems as well as male infertility. The ministry of health, ministry of agriculture and drug enforcement commission should take up the challenge and protect the ignorant users of ‘insunko’ Zambian herb.
Maybin Kalubula
University of Chinese Academy of Sciences, China
Title: Epidemiology of Kaposi’s sarcoma and the impact of HIV on the 1970 – 1979 generation in Zambia
Biography:
Will be updated soon.
Abstract:
Background
Kaposi’s sarcoma (KS) is the most prevalent HIV and AIDS-associated cancer worldwide. Zambia has been considered as part of the “KS belt”, where endemic KS has been prevalent. This study sought to assess the burden of Kaposi’s sarcoma and treatment modalities in Zambia from 2007 to 2014 and to identify major risk generations in the era of HIV.
Methods
A Time Series Cross Sectional (TSCS) study nested on the Zambia National Cancer Registry (ZNCR) histopathological and clinical Kaposi’s sarcoma data was conducted after ethical clearance from the Zambia National Research Authority. Central Statistics Office (CSO) demographic data were used to determine the prevalence and Age-specific rates while World Standard Population was used to determine Standardised Incidence Rate (SIR) and Standardised Mortality Rate (SMR). Our sample was 2521 (n = 2521). We used Graph Pad Prism version 7.04 and SPSS version 21 in our data analyses.
Results
KS has been highly prevalent in Lusaka, Central and Eastern Provinces of Zambia. It has also been more prevalent in males than in females with Mean distribution of 18.99 in males and 12.14 in females and 95% CI of 12.56 – 25.42 and 8.41 – 15.87 respectively. SIR was 22.97 per 100,000 population with 95% CI of 21.99 – 23.95. This study established a strong positive association between Kaposi’s sarcoma and HIV positive Kaposi’s sarcoma with p- value of
0.000. The 1970 – 1979 generation has been the most affected by KS. SMR was 122 with 92.9% of KS deaths occurring in HIV positive patients. The combination of Chemotherapy and Radiotherapy (62.9%) has been the most commonly used treatment modality in Zambia.
Conclusions
The high prevalence of KS in Zambia is as a result of the high prevalence of HIV. There is a need for a revised treatment strategy that would integrate nanoparticle therapeutics in the KS treatment scheme in Zambia. The identified two key intervention points for the reduction of KS morbidity are; the HIV infection point and improving highly active antiretroviral therapy (HAART) services. HIV health education for the youths should be intensified to create a strong HIV primary barrier which would result in a possibly future HIV free generation thereby reducing KS.