Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 30th Experts Meet On Cancer Therapy Melbourne, Australia.

Day 2 :

  • Session: Ethno pharmacology | Surgery | Cardiovascular Pharmacology | Cancer Stages | Toxicology | Robotic Surgery | Pharmacogenetics & Pharmacogenomics

Session Introduction

Dr Nasira Tajamal

MBBS, MPH, (Pak) MPH in Medical Epidemiology (USA), Islamabad Pakistan

Title: Incidence of Colorectal Carcinoma in Young Population of Islamabad
Biography:

Abstract:

The purpose of this study is to promote awareness concerning increased incidence of colorectal cancer in younger population and its clinical plus pathological features compared to older patients. This cross-sectional study was conducted from January 2017 to October 2017 on patients with diagnosis of colorectal carcinoma admitted through emergency or outpatient departments to surgical wards of PIMS Hospital, Islamabad. Data concerning age, gender, presentation, site of tumor, surgery performed and TNM staging was used for analysis.
Total numbers of patients studied were 27. Males were17 (63%) and females were 10 (37%). Patients between the ages of 10 to 20 were 4, (15%), out of these patients 2 were declared unfit for surgery because of wide spread tumor within the abdomen as well distant metastasis.  There were 9 (33%) patients between the ages of 21 to 30 and among these 4 was inoperable because of widespread disease. Patients between the ages of 31 to 40 were 5 (19%), 2 were inoperable, while cases between the ages of 41 to 50 were 4 (15%). There were 3 (11%) patients between the ages of 51 and 60 and 2 (7%) cases were between the ages of 61 to 70 years. Total 8 (30%) patients were inoperable and they were young patients, therefore colorectal carcinoma is more aggressive in young patients and 18 (82%) patients between the ages of 10 to 50 years had left sided disease.

Speaker
Biography:

Will be updated soon.

Abstract:

Data of 92 patients diagnosed with borderline ovarian tumours (BOTs) during the period from 2010 to 2017 in the National Cancer Institute (NCI), Cairo University, Egypt were retrospectively evaluated, Median follow up period was 42 months. The mean age at diagnosis was 42.7 yrs. Histopathology was serous in 63%, mucinous in 28.3%, and endometrioid in 3.3%. 65 patients (70.7%) had Stage IA disease, 17 patients had Stage IB disease (18.5%), 4 patients had Stage IC disease (4.3%), 2 patients had Stage II disease (2.2%) and 4 patients had Stage III disease (4.3%) at diagnosis .49 patients (53.3%) underwent fertility sparing surgery, of which 19 patients underwent Unilateral ovarian cystectomy, 5 patients underwent Bilateral ovarian cystectomy, 25 underwent Unilateral salpingo-oopherectomy.43 patients (46.7%) underwent radical surgery including hysterectomy, bilateral salpingo-oopherectomy.39 patients had micropapillary disease (42 %) and 2 patients had microinvasive disease (2.2%) on histopathology.6 patients (6.5 %) had peritoneal implants of which 1 was invasive and 5 were non-invasive. Recurrence rate in the entire study group was 18.5% , 17.6% among patients underwent radical surgery and 82.4% among patients underwent fertility sparing surgery. 12 of the recurrences (70.6%) were borderline whereas 5 were invasive (29.4%). Stages  IA and IB had significantly higher disease free survival than other stages. Patients with micro invasion had significantly lower free disease free survival 10.5 (9.52 – 11.5) Vs77.6 (70.9 – 84.1) .Radical surgery had significantly higher FDS than fertility sparing surgery 75.8 (70.2 – 81.4) Vs 68.5(58.2 – 78.8) 

Aarti Sharma

Govindrakshak Ayurvedic and Acupuncture centre ,Punjab

Title: Ayurveda a ray of hope for hepatocellular carcinoma
Speaker
Biography:

Dr Aarti Sharma born 1983  did Bachelor of Ayurvedic medicine and surgery (BAMS) from one of the premier Ayurvedic college , Govt . Ayurvedic college , Patiala (India) in 2007 . Since then she  has been practising ayurveda for the treatment  of  lifestyle disorders, stress, gynaeocolgical issues,hepatic disorders ,arthritis and other chronic ailments in her own clinic named Govindrakshak Ayurvedic and Acupuncture centre , Ludhiana (Punjab). During these years, she  also completed Masters in nutrition and dietetics, Post graduate diploma in Acupuncture and moxibustion , Post graduate diploma in yoga and naturopathy along with a short term course in panchkarma . Suggesting a patient about diet, yoga, naturopathy, panchkarma along with Ayurvedic medicines and healthy lifestyle has always helped her  patients for better recovery in a short span. She has been presenting her findings at various national and International conferences.Her work has been appreciated in all conferences.

Abstract:

Hepatocellular carcinoma (HCC) is a very fatal disease having its primary origin in liver. Chronic liver disease, Viral hepatitis,   alcohol abuse ,aflatoxins, hemochromatosis,  alcohol abuse, cirrhosis, exposure to various carcinogens and non alcoholic fatty liver disease are some of the major  risk factors  associated with  primary liver cell malignancy. The case presented here is of  male patient who  had a very  high value of AFP ( Alfa fetoprotein ) tumor marker. His Computed tomography scan and ultrasonography reports  clearly  diagnosed him  for hepatocellular carcinoma (liver cancer). He was given ayurvedic treatment for his hepatocellular carcinoma .He was prescribed herbal decoction of Giloya (Tinospora cordifolia), haldi (Curcuma longa) along with  triphala {combination of 3 herbs: amla (Phyllanthus emblica), harada (Terminalia chebula),  baheda (Terminalia bellirica)} along  with various ayurvedic  formulations  particularly punarnavarishta and kalmeghasav . Patient showed significant improvement with treatment . His chief complaints of nausea , right abdominal pain, loss of appetite  subsided in  forty days of  treatment . During course of treatment, patient was advised for AFP (Alfa fetoprotein) tumor marker test thrice and in all the three tests performed at different intervals, his reports were found to be in normal range . After around ten months of treatment, patient was advised for ultrasonography which showed miraculous improvement with no abnormality detected. This case study shows Ayurveda, science of life which is most ancient healing science offers a ray of hope for patients suffering from dreadful condition of liver cancer 

Speaker
Biography:

Abdolsaleh Jafari is PhD candidate in health economics at Iran University of Medical Sciences, Tehran, Iran and joined the Menzies Institute for Medical Research, University of Tasmania, Australia in July 2018 as adjunct researcher. Before starting PhD programme in Iran, Abdolsaleh worked as instructor and faculty member of department of health economics at Shiraz University of Medical Sciences in Iran for 3 years. Abdosaleh published more than 25 articles in peer review journals.

Abstract:

Chemotherapy for lymph node cancer is often composed of several drugs that are used in a treatment program. The aim of this study was to perform a cost-effectiveness analysis of IEV drug regimen (ifosfamide, epirubicin, and etoposide) versus ESHAP drug regimen (etoposide, methylprednisolone, high-dose cytarabine, and cisplatin) in patients with lymphoma in the south of Iran.

Speaker
Biography:

Will be updated soon.

Abstract:

Background

Cervical cancer is the most common cancer in Zambian women, and its upward trend in Zambia in the past decade is worrisome. Multiple sexual partners, early indulgence in sexual activities and the use of vaginal herbs among others have heightened the risk of contracting the Human Papilloma Virus infection, which is the major cause of cervical cancer.

Methods

A qualitative research design on the use of ‘insunko’ vaginal herb coupled with descriptive phenomenological approach was applied, which involved the retrospective and prospective cervical cancer data obtained from patients’ files at the Zambia Cancer Diseases Hospital (CDH). 10 focus group discussions from 10 hospitals across Zambia involving 30 (n =30) Gynecologists and Cervical Cancer Screening Nurses were conducted to determine the extent of use of ‘insunko’ vaginal herb. The samples were 5,719 (n = 5,719) for the descriptive study. Our study was authorised by the National Health Research Authority of Zambia.

Results

Cervical cancer in Zambia mostly affected age groups 30 – 39, 40 – 49 and 50 – 59 years. ‘Insunko’ herb is widely used in Zambia for sniffing (smoking) while women also use it vaginally for sexual pleasure of the male partner during sexual intercourse. Standardised Incidence Rates (SIR) for all ages have been very high in Monze (493.82; 95% CI = 431.07 – 556.57), Lusaka (413.11; 95% CI = 391.2 – 435.02), Katete (319.58; 95% CI = 276.91 – 362.25) and Chipata (305.04; 95% CI = 274.92 – 335.16). Multiple sexual partners and polygamist marriages are associated with cervical cancer incidence with correlation coefficient r = 0.710 and – value of 0.021. Age groups affected with cervical cancer are associated with women known to be using ‘insunko’ vaginal herb with – value = 0.019.

Conclusions

The upward trend of cervical cancer in Zambia has been triggered by the culture of having multiple sexual partners and early indulgence in sexual activities. The use of ‘insunko’ vaginal herb is a kind of sexual discrimination with serious health consequences in women. The government should initiate and implement policies to fight the ignorant sexual culture in order to protect women’s rights

 

Speaker
Biography:

Yu-Chen Enya Chen is studying her PhD degree at University of Queensland. Is on third year of PhD and has published a review paper as first author in BBA Cancer Review 2017 (Chen et al.). Is in progress in publishing her second paper. Her PhD project so far has presented an interesting study towards the understanding of the antibody resistant of patients with progressive chronic lymphocytic leukaemia disease. The study shows the evidence of the importance of macrophages as a major contributor to CLL diseases progression.

 

Abstract:

Antibody therapies for treating chronic lymphocytic leukaemia (CLL) remain a challenge for many CLL patients who are insensitive to antibody treatment. A high percentage of CLL patients that are resistant to the current combination therapy of chemotherapeutics and immune-therapeutics has always been a clinical challenge. Understanding the mechanisms driving disease progression and treatment resistance is key to improving patient outcomes. Many studies including our own laboratories have shown that resistance to therapeutic antibodies against CLL is due to the survival signals from the monocyte derived macrophages (MDMs), and also an acquired resistance of monocyte derived macrophages to participate in FcγR-dependent antitumour responses. However, the FcγR-dependent signalling pathway in macrophages has not been well studied. Our recently published data suggested that SYK and BTK are involved downstream of FcγR-dependent signalling pathway (referred to as ITAM; Oncogene, 36(17):2366-2376, 2017). In this study we investigate the involvement of PI3K isoforms as they have been known to be an important pathway regulator for cellular function in various immune cells such as T cells, B cells and NK cells as well as in cancerous cells. To examine the expression and involvement PI3K isoforms in contributing to FcγR-dependent ADCC by MDMs, we used different inhibitors to specifically target each PI3K isoform at a time to investigate the effect on ADCC responses by MDMs. Examination of PI3K expression showed that PI3Kα, β, and δ are expressed in MDM whereas PI3Kγ is below the limit of detection. We also reported that the PI3Kδ-selective inhibitor, idelalisib and the pan PI3K inhibitor BKM120 (Buparlisib) were able to inhibit ADCC in response to the CD20-targeting therapeutic antibody, obinutuzumab. Similarly, both buparlisib and idelalisib were able to inhibit AKT phosphorylation at concentrations that also inhibited ADCC.

This is the first report to show that PI3Kd is involved in FcgR signalling in MDMs from CLL patients or in MDMs from any tumour type. Based on these findings we conclude that PI3Kd is a critical effector molecule for antitumour responses to therapeutic antibodies in CLL.

Speaker
Biography:

Will be updated soon.

Abstract:

Background

There has emerged an herb in Zambia called ‘insunko’ which is widely used for snuffing while females also use it vaginally to make their private part tight and warm during sexual intercourse. The consumption of ‘insunko’ Zambian herb, which has an unknown chemical composition, has brought mixed feelings among many Zambians. This study therefore aimed at determining toxicity and carcinogenicity of ‘insunko’ Zambian herb.

Methods

Samples were collected from six of the ten provinces of Zambia namely; Eastern, Lusaka, Luapula, Muchinga, Copperbelt and North Western between 4th December 2017 and 4th February 2018 after ethical clearance from the National Health Research Authority of Zambia ‘Insunko’ Zambian herb was sampled by way of purchasing from Chipata, Lusaka, Mpika, Mwense, Kitwe and Solwezi (n = 6). ICP-MS Inductively Coupled Plasma Mass Spectroscopy (Agilent Technologies, Santa Clara, CA, USA) was used for toxic heavy metals analysis. 𝐶𝑎𝑟𝑐𝑖𝑛𝑜𝑔𝑒𝑛𝑖𝑐 risk = CDIing× 𝐵𝐴𝐹 × 𝑆𝐿𝐹; 𝐻𝑎𝑧𝑎𝑟𝑑 𝐼𝑛𝑑𝑒𝑥 (𝐻𝐼) = C DIing × 𝐵𝐴𝐹. 𝑅𝑓D0

Results

Toxic heavy metals have been detected in ‘insunko’ Zambian herb in high concentration. The Mean concentration ± SD in mg kg-1 was; Arsenic = 0.07 ± 0.04, Cadmium = 0.13 ± 0.05, Cobalt = 0.49 ± 0.27, Chromium = 1.46 ± 1.04, Copper = 5.58 ± 2.91, Manganese = 77.05 ± 35.29, Nickel = 0.91 ± 0.52 and Lead = 0.79 ± 1.22. Hazard Index for Chromium, Manganese, Copper and Arsenic was greater than one (HI > 1) implying that these heavy metals are toxic and carcinogenic to consumers of ‘insunko’ Zambian herb.

Conclusions

‘Insunko’ Zambian herb is toxic and carcinogenic as in contains toxic and carcinogenic heavy metals in high concentration. These toxic metals cause cancers, GIT disorders, degenerative, hematopoietic, cardiovascular, neurologic and cognitive problems as well as male infertility. The ministry of health, ministry of agriculture and drug enforcement commission should take up the challenge and protect the ignorant users of ‘insunko’ Zambian herb.

Biography:

Will be updated soon.

Abstract:

Background

Kaposi’s sarcoma (KS) is the most prevalent HIV and AIDS-associated cancer worldwide. Zambia has been considered as part of the “KS belt”, where endemic KS has been prevalent. This study sought to assess the burden of Kaposi’s sarcoma and treatment modalities in Zambia from 2007 to 2014 and to identify major risk generations in the era of HIV.

Methods

A Time Series Cross Sectional (TSCS) study nested on the Zambia National Cancer Registry (ZNCR) histopathological and clinical Kaposi’s sarcoma data was conducted after ethical clearance from the Zambia National Research Authority. Central Statistics Office (CSO) demographic data were used to determine the prevalence and Age-specific rates while World Standard Population was used to determine Standardised Incidence Rate (SIR) and Standardised Mortality Rate (SMR). Our sample was 2521 (n = 2521). We used Graph Pad Prism version 7.04 and SPSS version 21 in our data analyses.

Results

KS has been highly prevalent in Lusaka, Central and Eastern Provinces of Zambia. It has also been more prevalent in males than in females with Mean distribution of 18.99 in males and 12.14 in females and 95% CI of 12.56 – 25.42 and 8.41 – 15.87 respectively. SIR was 22.97 per 100,000 population with 95% CI of 21.99 – 23.95. This study established a strong positive association between Kaposi’s sarcoma and HIV positive Kaposi’s sarcoma with p- value of

0.000. The 1970 – 1979 generation has been the most affected by KS. SMR was 122 with 92.9% of KS deaths occurring in HIV positive patients. The combination of Chemotherapy and Radiotherapy (62.9%) has been the most commonly used treatment modality in Zambia.

Conclusions

The high prevalence of KS in Zambia is as a result of the high prevalence of HIV. There is a need for a revised treatment strategy that would integrate nanoparticle therapeutics in the KS treatment scheme in Zambia. The identified two key intervention points for the reduction of KS morbidity are; the HIV infection point and improving highly active antiretroviral therapy (HAART) services. HIV health education for the youths should be intensified to create a strong HIV primary barrier which would result in a possibly future HIV free generation thereby reducing KS.