Day 1 :
- Cancer Therapy & Immuno Oncology
Session Introduction
Devasis Ghosh
Belle Vue Clinic, India
Title: Hypothesis of a Holistic Treatment of Cancer: Crab Method
Biography:
Devasis Ghosh is an Independent Researcher in Mental Health, Belle Vue Clinic, Grace, India.
Abstract:
The main hindrance to total cure of cancer is a) the failure to control continued production of cancer cells, b) its sustenance and c) its metastasis. This review study has tried to address this issue of total cancer cure in a more innovative way. A 10-pronged “CRAB METHOD”, a novel holistic scientific approach of Cancer treatment has been hypothesized in this paper. Apart from available Chemotherapy, Radiotherapy and Oncosurgery, (which shall not be discussed here), seven other points of interference and treatment has been suggested, i.e. 1. Efficient stress management. 2. Dampening of ATF3 expression. 3. Selective inhibition of Platelet Activity. 4. Modulation of serotonin production, metabolism and 5HT receptor antagonism. 5. Auxin, its anti-proliferative potential and its modulation. 6. Melatonin supplementation because of its oncostatic properties. 7. HDAC Inhibitors especially valproic acid use due to its apoptotic role in many cancers. If all the above stated seven steps are thoroughly taken care of at the time of initial diagnosis of cancer along with the available treatment modalities of Chemotherapy, Radiotherapy and Oncosurgery, then perhaps, the morbidity and mortality rate of cancer may be greatly reduced.
Huang Wei Ling
Medical Acupuncture and Pain Management Clinic. Brazil
Title: How Can We do Preventive Measurements in Breast Cancer Without Asking for Any Laboratorial or Radiological Exams?
Biography:
Huang Wei Ling, born in Taiwan, raised and graduated in medicine in Brazil, specialist in infectious and parasitic diseases, a General Practitioner and Parenteral and Enteral Medical Nutrition Therapist. Once in charge of the Hospital Infection Control Service of the City of Franca’s General Hospital, she was responsible for the control of all prescribed antimicrobial medication and received an award for the best paper presented at the Brazilian Hospital Infection Control Congress in 1998.
Abstract:
Introduction: The earliest detection of cancer formation is the objective from all medicals systems as cancer in the early stage can be asymptomatic. A variety of techniques involving biomedical imaging are used in all phases of cancer measurements. According to traditional Chinese medicine, cancer comes from energy deficiency and Heat retention. Purpose; the purpose of this study is to demonstrate that there are tools that we can use to screening the prevention of cancer formation without using any laboratorial or image exam.
Methods; the author used some theories in traditional Chinese medicine concerning cancer formation and applied in her daily practice. In a research she did in her clinic measuring 1000 chakras’ energy centers from 2015 to 2020, using radiesthesia procedure, to see how were the energy of the population that she was attending her clinic in Brazil.
Results; more than 90% of the patients studied were in the minimum level of energy, rated one out of eight and all of them were considered high risks for acquiring cancer due to the complete lack of energy in this chakras’ energy centers, that are the energy deficiency responsible for the cancer formation if not properly treated accordingly.
Conclusion: there are other form of prevention of cancer without using any radiological and laboratorial exams such as the use of radiesthesia procedure to measure the energy in the chakras’ energy centers, that are responsible for the formation of Yin, Yang (Kidney or second chakra), Qi (distributed by the fourth chakra and or the Blood (produced by the fifth chakra and controlled the flow of the blood inside the vessels. The detection of patient with chakras’ energy deficiency is imperative in all patients nowadays, because of the influences of the electromagnetic waves in our life, harming our energy and the treatment of this condition using traditional Chinese medicine´s tools and homeopathies medications according to the theory Constitutional Homeopathy of the Five Elements based on Traditional Chinese Medicine are very important to prevention of cancer formation in health patients nowadays.
Stefan Grudén
Karolinska Institutet, Sweden
Title: Biodistribution of Fluorescence-labelled EGF Protein from Slow Release NanoZolid Depots in Mouse.
Biography:
Stefan Grudén is working at Experimental Cancer Medicine, Clinical Research Center, Karolinska Institutet, Stockholm Sweden.
Abstract:
Abstract— Aim: The study was designed to evaluate the ability of the calcium sulfate based NanoZolid® drug delivery technology to locally release the epidermal growth factor (EGF) protein while maintaining its biological activity.
Methods: NanoZolid-formulated EGF protein labelled with a near infrared dye (EGF-NIR) depots or EGF-NIR dissolved in PBS were injected subcutaneously into mice bearing EGF receptor (EGFR) positive human A549 lung cancer tumors inoculated subcutaneously. The release and biodistribution of the EGF-NIR were investigated in vivo longitudinally up to 96 hours post administration, utilizing whole body fluorescence imaging. In order to confirm the in vivo findings, histological analysis of tumor cryosections was performed to investigate EGF-NIR fluorescent signal and EGFR expression level by immunofluorescence labelling.
Results: The in vivo fluorescence imaging showed a controlled release profile of the EGF-NIR loaded in the NanoZolid depots compared to free EGF-NIR. Histological analysis of the tumors further demonstrated a prevailing distribution of EGF-NIR in regions with high levels of EGFR expression.
Conclusion: Calcium sulfate based depots can be used to formulate EGF while maintaining its biological activity, e.g. receptor binding capability. This may have a good clinical potential for local delivery of biomolecules to enhance treatment efficacy and minimize systemic adverse effects.
Natalia Camejo
Universidad de la República, Uruguay
Title: Prevalence of Trastuzumab-induced cardiotoxicity in Uruguayan HER-2 positive breast cancer patients treated in a real life setting during a 10 years period
Biography:
Natalia Camejo Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología. Montevideo, Uruguay.
Abstract:
Objective: To estimate the prevalence of Trastuzumab (TTZ) induced cardiotoxicity in Uruguayan women diagnosed with early HER – 2 positive breast cancer (BC) over a period of ten years, treated under the financial coverage of the National Resource Fund (FNR).
Methodology: A prospective descriptive observational study based on the analysis of an anonymized database provided by the FNR of Uruguayan HER-2 positive early BC patients treated with TTZ between 2006 and 2016. Variables analyzed included: age, menopausal status, stage, presence of cardiovascular risk factors, use or not of anthracyclines, left ventricular ejection fraction prior and during treatment, and temporary or permanent suspension of treatment. Statistical analysis was performed using SPSS Statistics version 25. The variables were assessed through the use of measures of central tendency, dispersion, contingency tables and proportions. To analyze the relationship between the different variables, the Chi-Square test of independence was performed.
Results: The analysis included 1401 patients diagnosed with HER-2 + stage I to III breast cancer who received adjuvant TTZ. The mean age at diagnosis was 52.45 years. The prevalence of cardiotoxicity in evaluable patients (1065 pts) was 20.3%. The proportion of patients who had symptomatic heart failure was 3% (32 pts) and in those who discontinued treatment for asymptomatic cardiac toxicity managed to resume trastuzumab prevalence was 92.6 %. About 9,7 % (21 pts) of patients had drop of left ventricular ejection fraction (LVEF) below 50%, whilst 10% drop of LVEF below their baseline levels were found in 75% of patients (162 pts) There is significant difference in the risk of cardiotoxicity according to the type of chemotherapy (anthracycline containing vs non-anthracycline based) (Chi-square= 3.9, p-value < 0.005). There was no evidence of a relationship between cardiovascular risk factors and the development of cardiotoxicity as well there was no evidence between sequential or concurrent use of TTZ with chemotherapy.
Conclusion: The prevalence of cardiotoxicity in this study was similar to that reported internationally. The majority of patients did not develop cardiac toxicity and those who presented it did so asymptomatically and reversibly.